This paper explores the nexus between trade, employment, and unionisation in Africa. While highlighting the narrative that international trade enables economic growth, productive efficiency, job creation, and income growth, this paper also points out the significant impact of trade liberalisation on trade unions. Specifically, the paper highlights the profound impact that trade liberalisation has had on trade unions on the continent through its adverse impacts on job quantity and quality. Given the scale and severity of these labour market impacts, especially in the context of the African Continental Free Trade Area (AfCFTA), the paper underscores the urgent need for trade unions to engage more effectively with national and supranational authorities on trade policies. The paper proposes several policy options for trade unions, including integrating trade advocacy into union activities, participation in national and continental trade policy dialogues, and monitoring trade developments. Additionally, the paper calls for harmonised trade advocacy across unions, campaign for strengthening of labour regulations, and the promotion of international solidarity and alliances. While these policy recommendations are not a panacea, they offer African trade unions a pathway to revitalisation and greater influence in shaping trade and labour policies on the continent.